Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC6295266 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Wang Zhaoming Z Liu Qi Q Wilson Carmen L CL Easton John J Mulder Heather H Chang Ti-Cheng TC Rusch Michael C MC Edmonson Michael N MN Rice Stephen V SV Ehrhardt Matthew J MJ Howell Rebecca M RM Kesserwan Chimene A CA Wu Gang G Nichols Kim E KE Downing James R JR Hudson Melissa M MM Zhang Jinghui J Yasui Yutaka Y Robison Leslie L LL
Clinical cancer research : an official journal of the American Association for Cancer Research 20181026 24
<h4>Purpose</h4>The risk of subsequent breast cancer among female childhood cancer survivors is markedly elevated. We aimed to determine genetic contributions to this risk, focusing on polygenic determinants implicated in breast cancer susceptibility in the general population.<h4>Experimental design</h4>Whole-genome sequencing (30×) was performed on survivors in the St Jude Lifetime Cohort, and germline mutations in breast cancer predisposition genes were classified for pathogenicity. A polygeni ...[more]