Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome.

ABSTRACT:

Study question

What are the causal relationships between polycystic ovary syndrome (PCOS) and body mass index (BMI)?

Summary answer

Bidirectional Mendelian randomization analyses suggest that increased BMI is causal for PCOS while the reverse is not the case.

What is known already

The contribution of obesity to the pathogenesis of PCOS is controversial. To date, published genetic studies addressing this question have generated conflicting results and have not utilized the full extent of known single nucleotide polymorphisms associated with body mass index (BMI).

Study design, size, duration

This cross-sectional Mendelian randomization (MR) and genetic association study was conducted in 750 individuals of European origin and with PCOS and 1567 BMI-matched contro

SUBMITTER: Brower MA 

PROVIDER: S-EPMC6295958 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature