Qualitative modelling of the interplay of inflammatory status and butyrate in the human gut: a hypotheses about robust bi-stability.

ABSTRACT:

Background

Gut microbiota interacts with the human gut in multiple ways. Microbiota composition is altered in inflamed gut conditions. Likewise, certain microbial fermentation products as well as the lipopolysaccharides of the outer membrane are examples of microbial products with opposing influences on gut epithelium inflammation status. This system of intricate interactions is known to play a core role in human gut inflammatory diseases. Here, we present and analyse a simplified model of bidirectional interaction between the microbiota and the host: in focus is butyrate as an example for a bacterial fermentation product with anti-inflammatory properties.

Results

We build a dynamical model based on an existing model of inflammatory regulation in gut epithelial cells. Our mo

SUBMITTER: Neumann G 

PROVIDER: S-EPMC6296070 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature