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Prognostic values of S100 family members in ovarian cancer patients.

ABSTRACT: OBJECTIVE:Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, inflammation and differentiation and the like. While the prognostic value of each individual S100 in ovarian cancer is still elusive. In current study, we investigated the prognostic value of S100 family members in the ovarian cancer. METHODS:We used the Kaplan Meier plotter (KM plotter) database, in which updated gene expression data and survival information are from 1657 ovarian cancer patients, to assess the relevance of individual S100 family mRNA expression to overall survival in various ovarian cancer subtypes and different clinicopathological features. RESULTS:It was found that high expression of S100A2 (HR?=?1.18, 95%CI: 1.04-1.34, P?=?0.012), S100A7A (HR?=?1.3, 95%CI: 1.04-1.63, P?=?0.02),S100A10 (HR?=?1.2, 95%CI: 1.05-1.38, P?=?0.0087),and S100A16 (HR?=?1.23, 95%CI: 1-1.51, P?=?0.052) were significantly correlated with worse OS in all ovarian cancer patients, while the expression of S100A1 (HR?=?0.87, 95%CI: 0.77-0.99, P?=?0.039), S100A3 (HR?=?0.83, 95%CI: 0.71-0.96, P?=?0.0011), S100A5 (HR?=?0.84, 95%CI: 0.73-0.97, P?=?0.017), S100A6 (HR?=?0.84, 95%CI: 0.72-0.98, P?=?0.024), S100A13 (HR?=?0.85, 95%CI:0.75-0.97, P?=?0.014) and S100G (HR?=?0.86, 95%CI: 0.74-0.99, P?=?0.041) were associated with better prognosis. Furthermore, we assessed the prognostic value of S100 expression in different subtypes and the clinicopathological features, including pathological grades, clinical stages and TP53 mutation status, of ovarian cancer patients. CONCLUSION:Comprehensive understanding of the S100 family members may have guiding significance for the diagnosis and outcome of ovarian cancer patients.

SUBMITTER: Bai Y

PROVIDER: S-EPMC6296138 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Prognostic values of S100 family members in ovarian cancer patients.

Bai Yang Y Li Liang-Dong LD Li Jun J Lu Xin X

BMC cancer 20181217 1

<h4>Objective</h4>Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, inflammation and differentiation and the like. While the prognostic value of each individual S100 in ovarian cancer is still elusive. In current study, we investigated the prognostic value of S100 family members in the ovarian cancer.<h4>Methods</h4>We used the Kaplan Meie ...[more]

PMID: 30558666

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Project description:BackgroundBreast cancer (BC) is one of the most lethal malignant tumors and the leading cause of cancer-related death worldwide. Although early diagnostic techniques for BC have been well developed, 40% of cases are still diagnosed at the advanced stage, while for BC patients with distant metastases, the 5-year survival rate is usually lower than 30%. The Snail family, generally regarded as transcriptional repressors, has been indicated to be an essential prognostic factor in malignant tumors. However, limited data exist on public databases concerning the prognostic value of individual Snail family members in BC, especially SNAI3.MethodsData from public databases including cBioPortal for Cancer Genomics, Gene Expression Omnibus, UCSC Xena Browser, and Human Protein Atlas (HPA) were downloaded. Based on the Kaplan¬-Meier plotter platform, correlation of the three members of the Snail family and prognosis in BC were analyzed. Individual Snail family members and their co-expressed genes were respectively enriched on different pathways and biological processes via the functional enrichment analysis (FunRich) tool.ResultsHigh SNAI1 mRNA expression was associated with shorter distant metastasis-free survival (DMFS) in all BC patients regardless of PAM50 subtype. Conversely, high SNAI3 mRNA expression was associated with longer DMFS. Although the presence of SNAI2 expression was significantly associated with DMFS in the whole cohort, no significant correlation was found in patients with luminal A or HER2 subtype. For patients with the most diverse clinicopathological features, high SNAI1 expression was associated with poor survival, with the converse being true for SNAI3. However, the impact on prognosis of patients with different clinicopathological features produced by SNAI2 expression was inconclusive. Furthermore, we discovered that SNAI1 or SNAI2 and their co-expressed genes frequently enriched receptor tyrosine kinase (RTK) signaling and integrin-related pathways which mainly functioned on epithelial-mesenchymal transition and were further involved in several processes of signal transduction and cell communication. Furthermore, as SNAI3, along with its co-expressed genes, enriched immune-related pathways, it may thus play a role in mediating the immune system.ConclusionsOur analysis revealed that SNAI1 mRNA expression may potentially be a negative prognostic factor, whereas SNAI3 mRNA was associated with positive prognosis in BC. Therefore, the assessment of SNAI1 and SNAI3 expression may be valuable for predicting prognosis in BC patients.

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Prognostic values of S100 family members in ovarian cancer patients.

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Prognostic values of S100 family members in ovarian cancer patients.

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