Dataset Information

Statins associate with improved mortality among patients with certain histological subtypes of lung cancer.

ABSTRACT: OBJECTIVES:To measure the association between statin exposure and mortality in lung cancer patients belonging to different categories of histological subtype. MATERIALS AND METHODS:A cohort of 19,974 individuals with incident lung cancer between 2007 and 2011 was identified using the SEER-Medicare linked database. Statin exposure both pre- and post-diagnosis was analyzed to identify a possible association with cancer-specific mortality in patients stratified by histological subtype. Intention-to-treat analyses and time-dependent Cox regression models were used to calculate hazard ratios and 95% confidence intervals (95% CIs) corresponding to statin exposure both pre- and post-diagnosis, respectively. RESULTS:Overall baseline statin exposure was associated with a decrease in mortality risk for squamous-cell carcinoma patients (HR?=?0.89, 95% CI?=?0.82-0.96) and adenocarcinoma patients (HR?=?0.87, 95% CI?=?0.82-0.94), but not among those with small-cell lung cancer. Post-diagnostic statin exposure was associated with prolonged survival in squamous-cell carcinoma patients (HR?=?0.68, 95% CI?=?0.59-0.79) and adenocarcinoma patients (HR?=?0.78, 95% CI?=?0.68-0.89) in a dose-dependent manner. CONCLUSION:There is consistent evidence indicating that baseline or post-diagnostic exposure to simvastatin and atorvastatin is associated with extended survival in non-small-cell lung cancer subtypes. These results warrant further randomized clinical trials to evaluate subtype-specific effects of certain statins in patient cohorts with characteristics similar to those examined in this study.

SUBMITTER: Ung MH

PROVIDER: S-EPMC6296763 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Statins associate with improved mortality among patients with certain histological subtypes of lung cancer.

Ung Matthew H MH MacKenzie Todd A TA Onega Tracy L TL Amos Christopher I CI Cheng Chao C

Lung cancer (Amsterdam, Netherlands) 20181025

<h4>Objectives</h4>To measure the association between statin exposure and mortality in lung cancer patients belonging to different categories of histological subtype.<h4>Materials and methods</h4>A cohort of 19,974 individuals with incident lung cancer between 2007 and 2011 was identified using the SEER-Medicare linked database. Statin exposure both pre- and post-diagnosis was analyzed to identify a possible association with cancer-specific mortality in patients stratified by histological subtyp ...[more]

PMID: 30527197

Similar Datasets

Project description:BackgroundPrevious studies have reported differential associations of certain dietary factors such as soy consumption by epidermal growth factor receptor mutant (EGFR +) subtype of non-small cell lung cancer (NSCLC). However, whether the other dietary factors including meat, fruits, and vegetables have differential risks on different histological and molecular subtypes of lung cancer remains unclear. Therefore, we conducted a case-control study to evaluate these associations.MethodsA total of 3,170 cases and 4,238 controls from three different studies (Genes and Environment in Lung Cancer Study, Lung Cancer Consortium Singapore Study, and Multi-ethnic Cohort Study) were included. Information on demographics, lifestyle, and dietary consumption was obtained using questionnaires. Diet was assessed by using the number of standard servings of each item consumed per week. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between meat, vegetables, and fruits consumption with lung cancer risk after adjusting for potential confounders.ResultsWe identified a significant inverse association between higher consumption of fruits and the risk of lung cancer (2nd tertile: OR = 0.54, 95%CI = 0.46-0.65; 3rd tertile: OR = 0.77, 95%CI = 0.65-0.91), compared with the lower (1st tertile) consumption of fruits. Higher vegetable consumption was significantly associated with a lower risk of EGFR + lung cancer (OR = 0.69, 95% CI = 0.54-0.88), however, this association was not significant among EGFR wild-type (-) lung cancer. Conversely, higher consumption of total meat (OR = 2.10, 95%CI = 1.58-2.79) was significantly associated with higher lung cancer risk, as compared with the lower consumption group.ConclusionsDifferential associations between vegetable consumption with EGFR mutation status in NSCLC were found. Further prospective studies are warranted to assess this association and elucidate the biological mechanisms.

Dataset Information

Statins associate with improved mortality among patients with certain histological subtypes of lung cancer.

Publications

Statins associate with improved mortality among patients with certain histological subtypes of lung cancer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets