ICU survival and need of renal replacement therapy with respect to AKI duration in critically ill patients.

ABSTRACT: BACKGROUND:Transient and persistent acute kidney injury (AKI) could share similar physiopathological mechanisms. The objective of our study was to assess prognostic impact of AKI duration on ICU mortality. DESIGN:Retrospective analysis of a prospective database via cause-specific model, with 28-day ICU mortality as primary end point, considering discharge alive as a competing event and taking into account time-dependent nature of renal recovery. Renal recovery was defined as a decrease of at least one KDIGO class compared to the previous day. SETTING:23 French ICUs. PATIENTS:Patients of a French multicentric observational cohort were included if they suffered from AKI at ICU admission between 1996 and 2015. INTERVENTION:None. RESULTS:A total of 5242 patients were included. Initial severity according to KDIGO creatinine definition was AKI stage 1 for 2458 patients (46.89%), AKI stage 2 for 1181 (22.53%) and AKI stage 3 for 1603 (30.58%). Crude 28-day ICU mortality according to AKI severity was 22.74% (n?=?559), 27.69% (n?=?327) and 26.26% (n?=?421), respectively. Renal recovery was experienced by 3085 patients (58.85%), and its rate was significantly different between AKI severity stages (P?

SUBMITTER: Truche AS 

PROVIDER: S-EPMC6297118 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature