Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Fabregas J
PROVIDER: S-EPMC6297226 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Martínez-Fábregas Jonathan J Prescott Alan A van Kasteren Sander S Pedrioli Deena Leslie DL McLean Irwin I Moles Anna A Reinheckel Thomas T Poli Valeria V Watts Colin C
Nature communications 20181217 1
Diverse cellular processes depend on the lysosomal protease system but how cells regulate lysosomal proteolytic capacity is only partly understood. We show here that cells can respond to protease/substrate imbalance in this compartment by de novo expression of multiple lysosomal hydrolases. This response, exemplified here either by loss of asparagine endopeptidase (AEP) or other lysosomal cysteine proteases, or by increased endocytic substrate load, is not dependent on the transcription factor E ...[more]