Free D-amino acids produced by commensal bacteria in the colonic lumen.
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ABSTRACT:
SUBMITTER: Matsumoto M
PROVIDER: S-EPMC6297366 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Free D-amino acids produced by commensal bacteria in the colonic lumen.
Matsumoto Mitsuharu M Kunisawa Akihiro A Hattori Takanari T Kawana Shuichi S Kitada Yusuke Y Tamada Hazuki H Kawano Shinichi S Hayakawa Yoshihiro Y Iida Junko J Fukusaki Eiichiro E
Scientific reports 20181217 1
D-amino acids (D-AAs) have various biological activities, such as activation of N-methyl-D-aspartic acid (NMDA) receptor as a co-agonist by D-Ser. Since several free D-AAs are released in the broth monocultured with bacterium and D-AAs are probably utilized for bacterial communication, we presume that intestinal microbiota releases several kinds of free D-AAs, which may be involved in the hosts' health. However, presently, only four free D-AAs have been found in the ceacal lumen, but not in the ...[more]
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