BrainEXP: a database featuring with spatiotemporal expression variations and co-expression organizations in human brains.
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ABSTRACT: Summary
Gene expression changes over the lifespan and varies among different tissues or cell types. Gene co-expression also changes by sex, age, different tissues or cell types. However, gene expression under the normal state and gene co-expression in the human brain has not been fully defined and quantified. Here we present a database named Brain EXPression Database (BrainEXP) which provides spatiotemporal expression of individual genes and co-expression in normal human brains. BrainEXP consists of 4567 samples from 2863 healthy individuals gathered from existing public databases and our own data, in either microarray or RNA-Seq library types. We mainly provide two analysis results based on the large dataset: (i) basic gene expression across specific brain regions, age ranges and sexes; (ii) co-expression analysis from different platforms.Availability and implementation
http://www.brainexp.org/.Supplementary information
Supplementary data are available at Bioinformatics online.
SUBMITTER: Jiao C
PROVIDER: S-EPMC6298050 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
BrainEXP: a database featuring with spatiotemporal expression variations and co-expression organizations in human brains.
Jiao Chuan C Yan Pengpeng P Xia Cuihua C Shen Zhaoming Z Tan Zexi Z Tan Yanyan Y Wang Kangli K Jiang Yi Y Huang Lingling L Dai Rujia R Wei Yu Y Xia Yan Y Meng Qingtuan Q Ouyang Yanmei Y Yi Liu L Duan Fangyuan F Dai Jiacheng J Zhao Shunan S Liu Chunyu C Chen Chao C
Bioinformatics (Oxford, England) 20190101 1
<h4>Summary</h4>Gene expression changes over the lifespan and varies among different tissues or cell types. Gene co-expression also changes by sex, age, different tissues or cell types. However, gene expression under the normal state and gene co-expression in the human brain has not been fully defined and quantified. Here we present a database named Brain EXPression Database (BrainEXP) which provides spatiotemporal expression of individual genes and co-expression in normal human brains. BrainEXP ...[more]
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