Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC6298075 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Liu Shi S Cheloha Ross W RW Watanabe Tomoyuki T Gardella Thomas J TJ Gellman Samuel H SH
Proceedings of the National Academy of Sciences of the United States of America 20181115 49
Human parathyroid hormone (PTH) and N-terminal fragments thereof activate two receptors, hPTHR1 and hPTHR2, which share ∼51% sequence similarity. A peptide comprising the first 34 residues of PTH is fully active at both receptors and is used to treat osteoporosis. We have used this system to explore the hypothesis that backbone modification of a promiscuous peptidic agonist can provide novel receptor-selective agonists. We tested this hypothesis by preparing a set of variants of PTH(1-34)-NH<sub ...[more]