Ontology highlight
ABSTRACT:
SUBMITTER: Alexander EJ
PROVIDER: S-EPMC6298105 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Alexander Elizabeth J EJ Ghanbari Niaki Amirhossein A Zhang Tao T Sarkar Jaya J Liu Yang Y Nirujogi Raja Sekhar RS Pandey Akhilesh A Myong Sua S Wang Jiou J
Proceedings of the National Academy of Sciences of the United States of America 20181115 49
The ubiquitin-like protein ubiquilin 2 (UBQLN2) has been genetically and pathologically linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but its normal cellular functions are not well understood. In a search for UBQLN2-interacting proteins, we found an enrichment of stress granule (SG) components, including ALS/FTD-linked heterogeneous ribonucleoprotein fused in sarcoma (FUS). Through the use of an optimized SG detection method, we o ...[more]