Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
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ABSTRACT:
SUBMITTER: Pulit SL
PROVIDER: S-EPMC6298238 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
Pulit Sara L SL Stoneman Charli C Morris Andrew P AP Wood Andrew R AR Glastonbury Craig A CA Tyrrell Jessica J Yengo Loïc L Ferreira Teresa T Marouli Eirini E Ji Yingjie Y Yang Jian J Jones Samuel S Beaumont Robin R Croteau-Chonka Damien C DC Winkler Thomas W TW Hattersley Andrew T AT Loos Ruth J F RJF Hirschhorn Joel N JN Visscher Peter M PM Frayling Timothy M TM Yaghootkar Hanieh H Lindgren Cecilia M CM
Human molecular genetics 20190101 1
More than one in three adults worldwide is either overweight or obese. Epidemiological studies indicate that the location and distribution of excess fat, rather than general adiposity, are more informative for predicting risk of obesity sequelae, including cardiometabolic disease and cancer. We performed a genome-wide association study meta-analysis of body fat distribution, measured by waist-to-hip ratio (WHR) adjusted for body mass index (WHRadjBMI), and identified 463 signals in 346 loci. Her ...[more]
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