Effects of multi-modal cues on conditioned place preference in C57BL/6J and DBA/2J mice.

ABSTRACT:

Rationale

Previous work has shown that some mouse strains (e.g., DBA/2J [D2]) readily develop robust ethanol-induced conditioned place preference (CPP) while others (e.g., C57BL/6J [B6]) do not. Though commonly interpreted as a difference between strains in sensitivity to ethanol reward, other explanations for this finding are possible.

Objectives

To explore the hypothesis that variation in sensitivity to contextual cues underlies CPP differences, the present work investigated ethanol-induced CPP in D2 and B6 mice trained with a standard tactile (floor) cue procedure compared to mice trained with tactile plus visual-spatial cues.

Methods

In an unbiased CPP procedure, mice were assigned to either a single element cue (one-compartment apparatus with tactile cue presente

SUBMITTER: Cunningham CL 

PROVIDER: S-EPMC6298874 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature