Ontology highlight
ABSTRACT:
SUBMITTER: Jin D
PROVIDER: S-EPMC6298900 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Jin Denan D Takai Shinji S Nonaka Yosuke Y Yamazaki Satoko S Fujiwara Masatoshi M Nakamura Yoshikazu Y
Molecular therapy. Nucleic acids 20181113
We have reported that mast cell chymase, an angiotensin II-generating enzyme, is important in cardiovascular tissues. Recently, we developed a new chymase-specific inhibitory RNA aptamer, HA28, and we evaluated the effects of HA28 on cardiac function and the mortality rate after myocardial infarction. Echocardiographic parameters, such as the left ventricular ejection fraction, fractional shortening, and the ratio of early to late ventricular filling velocities, were significantly improved by tr ...[more]