Ontology highlight
ABSTRACT:
SUBMITTER: Jia Q
PROVIDER: S-EPMC6299138 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Jia Qingzhu Q Wu Wei W Wang Yuqi Y Alexander Peter B PB Sun Chengdu C Gong Zhihua Z Cheng Jia-Nan JN Sun Huaibo H Guan Yanfang Y Xia Xuefeng X Yang Ling L Yi Xin X Wan Yisong Y YY Wang Haidong H He Ji J Futreal P Andrew PA Li Qi-Jing QJ Zhu Bo B
Nature communications 20181218 1
Combining whole exome sequencing, transcriptome profiling, and T cell repertoire analysis, we investigate the spatial features of surgically-removed biopsies from multiple loci in tumor masses of 15 patients with non-small cell lung cancer (NSCLC). This revealed that the immune microenvironment has high spatial heterogeneity such that intratumoral regional variation is as large as inter-personal variation. While the local total mutational burden (TMB) is associated with local T-cell clonal expan ...[more]