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Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer.

ABSTRACT: BACKGROUND:Adenosine-to-inosine (A-to-I) RNA editing is catalyzed by adenosine deaminases acting on RNA (ADAR) enzymes. Recent evidence suggests that RNA editing of antizyme inhibitor 1 (AZIN1) RNA is emerging as a key epigenetic alteration underlying cancer pathogenesis. METHODS:We evaluated AZIN1 RNA editing levels, and the expression of its regulator, ADAR1, in 280 gastric tissues from 140 patients, using a RNA editing site-specific quantitative polymerase chain reaction assays. We also analyzed the clinical significance of these results as disease biomarkers in gastric cancer (GC) patients. RESULTS:Both AZIN1 RNA editing levels and ADAR1 expression were significantly elevated in GC tissues compared with matched normal mucosa (P?

SUBMITTER: Okugawa Y 

PROVIDER: S-EPMC6299520 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer.

Okugawa Yoshinaga Y   Toiyama Yuji Y   Shigeyasu Kunitoshi K   Yamamoto Akira A   Shigemori Tsunehiko T   Yin Chengzeng C   Ichikawa Takashi T   Yasuda Hiromi H   Fujikawa Hiroyuki H   Yoshiyama Shigeyuki S   Hiro Junichiro J   Ohi Masaki M   Araki Toshimitsu T   Kusunoki Masato M   Goel Ajay A  

Journal of translational medicine 20181218 1

<h4>Background</h4>Adenosine-to-inosine (A-to-I) RNA editing is catalyzed by adenosine deaminases acting on RNA (ADAR) enzymes. Recent evidence suggests that RNA editing of antizyme inhibitor 1 (AZIN1) RNA is emerging as a key epigenetic alteration underlying cancer pathogenesis.<h4>Methods</h4>We evaluated AZIN1 RNA editing levels, and the expression of its regulator, ADAR1, in 280 gastric tissues from 140 patients, using a RNA editing site-specific quantitative polymerase chain reaction assays  ...[more]

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