Ontology highlight
ABSTRACT:
SUBMITTER: Dehler S
PROVIDER: S-EPMC6299844 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Dehler Sascha S Lou Wilson Pak-Kin WP Gao Liang L Skabkin Maxim M Dällenbach Sabrina S Neumann Andreas A Martin-Villalba Ana A
Frontiers in molecular neuroscience 20181211
External stimuli such as injury, learning, or stress influence the production of neurons by neural stem cells (NSCs) in the adult mammalian brain. These external stimuli directly impact stem cell activity by influencing areas directly connected or in close proximity to the neurogenic niches of the adult brain. However, very little is known on how distant injuries affect NSC activation state. In this study, we demonstrate that a thoracic spinal transection injury activates the distally located hi ...[more]