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Comparative transcriptomic analysis of bovine papillomatosis.


ABSTRACT: BACKGROUND:Bovine papillomavirus (BPV) belongs to the Papillomaviridae family and infects epithelial cells of bovines and closely related animals, causing hyperproliferative lesions known as warts or papillomas, which may regress or progress to form benign or malignant tumors. The virus enters the host cell and interacts with it by altering the regulation of genes that are responsible for controlling the cell cycle, thus triggering lesion formation. It is not yet known which host genes are regulated by viral infection. Therefore, the objective of this study was to make use of next-generation RNA sequencing methods to identify differentially expressed genes associated with BPV infection, which might elucidate possible marker genes that could be used to control the disease. RESULTS:Transcriptome analysis revealed that 1343 genes were differentially regulated (FDR?

SUBMITTER: Barreto DM 

PROVIDER: S-EPMC6300001 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Comparative transcriptomic analysis of bovine papillomatosis.

Barreto Débora M DM   Barros Gerlane S GS   Santos Lucas A B O LABO   Soares Rosilene C RC   Batista Marcus V A MVA  

BMC genomics 20181219 1


<h4>Background</h4>Bovine papillomavirus (BPV) belongs to the Papillomaviridae family and infects epithelial cells of bovines and closely related animals, causing hyperproliferative lesions known as warts or papillomas, which may regress or progress to form benign or malignant tumors. The virus enters the host cell and interacts with it by altering the regulation of genes that are responsible for controlling the cell cycle, thus triggering lesion formation. It is not yet known which host genes a  ...[more]

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