Ontology highlight
ABSTRACT:
SUBMITTER: Aithal A
PROVIDER: S-EPMC6300140 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Aithal Abhijit A Rauth Sanchita S Kshirsagar Prakash P Shah Ashu A Lakshmanan Imayavaramban I Junker Wade M WM Jain Maneesh M Ponnusamy Moorthy P MP Batra Surinder K SK
Expert opinion on therapeutic targets 20180726 8
<h4>Introduction</h4>MUC16 is overexpressed in multiple cancers and plays an important role in tumorigenicity and acquired resistance to therapy. Area covered: In this review, we describe the role of MUC16 under normal physiological conditions and during tumorigenesis. First, we provide a summary of research on MUC16 from its discovery as CA125 to present anti-MUC16 therapy trials that are currently in the initial phases of clinical testing. Finally, we discuss the reasons for the limited effect ...[more]