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Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling.

ABSTRACT: An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important ?-CF₃ pyridines, through the regioselective, sequential formation of two C-C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules.

SUBMITTER: Chen D

PROVIDER: S-EPMC6301205 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling.

Chen Dan D Xu Lei L Long Tianyu T Zhu Shengqing S Yang Jun J Chu Lingling L

Chemical science 20181002 48

An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important β-CF3 pyridines, through the regioselective, sequential formation of two C-C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules. ...[more]

PMID: 30647893

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