Ontology highlight
ABSTRACT:
SUBMITTER: Walther E
PROVIDER: S-EPMC6301713 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Walther Elisabeth E Boldt Sabrina S Kage Hirokazu H Lauterbach Tom T Martin Karin K Roth Martin M Hertweck Christian C Sauerbrei Andreas A Schmidtke Michaela M Nett Markus M
GMS infectious diseases 20161128
Zincophorin is a polyketide antibiotic that possesses potent activity against Gram-positive bacteria, including human pathogens. While a number of total syntheses of this highly functionalized natural product were reported since its initial discovery, the genetic basis for the biosynthesis of zincophorin has remained unclear. In this study, the co-linearity inherent to polyketide pathways was used to identify the zincophorin biosynthesis gene cluster in the genome of the natural producer <i>Stre ...[more]