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Clinics in diagnostic imaging (193). Sporadic Creutzfeldt-Jakob disease (sCJD).


ABSTRACT: A 68-year-old man presented with a three-week history of rapidly progressive dementia, gait ataxia and myoclonus. Subsequent electroencephalography showed periodic sharp wave complexes, and cerebrospinal fluid assay revealed the presence of a 14-3-3 protein. A probable diagnosis of sporadic Creutzfeldt-Jakob disease was made, which was further supported by magnetic resonance (MR) imaging of the brain showing asymmetric signal abnormality in the cerebral cortices and basal ganglia. The aetiology, clinical features, diagnostic criteria, various MR imaging patterns and radiologic differential diagnosis of sporadic Creutzfeldt-Jakob disease are discussed in this article.

SUBMITTER: Li JSY 

PROVIDER: S-EPMC6301874 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Clinics in diagnostic imaging (193). Sporadic Creutzfeldt-Jakob disease (sCJD).

Li Jun Si Yuan JSY   Lim Kheng Choon KC   Lim Winston Eng Hoe WEH   Chen Robert Chun RC  

Singapore medical journal 20181201 12


A 68-year-old man presented with a three-week history of rapidly progressive dementia, gait ataxia and myoclonus. Subsequent electroencephalography showed periodic sharp wave complexes, and cerebrospinal fluid assay revealed the presence of a 14-3-3 protein. A probable diagnosis of sporadic Creutzfeldt-Jakob disease was made, which was further supported by magnetic resonance (MR) imaging of the brain showing asymmetric signal abnormality in the cerebral cortices and basal ganglia. The aetiology,  ...[more]

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