Ontology highlight
ABSTRACT:
SUBMITTER: Jiang Y
PROVIDER: S-EPMC6302166 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Jiang Yuan Y Yan Long L Xia Longkuo L Lu Xiaoyin X Zhu Wenliang W Ding Dewen D Du Mingxia M Zhang Da D Wang Hongmei H Hu Baoyang B
The Journal of biological chemistry 20181018 50
Human pluripotent stem cells hold great promise for improving regenerative medicine. However, a risk for tumor formation and difficulties in generating large amounts of subtype derivatives remain the major obstacles for clinical applications of stem cells. Here, we discovered that zinc finger E-box-binding homeobox 1 (<i>ZEB1</i>) is highly expressed upon differentiation of human embryonic stem cells (hESCs) into neuronal precursors. CRISPR/Cas9-mediated <i>ZEB1</i> depletion did not impede neur ...[more]