Ontology highlight
ABSTRACT:
SUBMITTER: Yeang C
PROVIDER: S-EPMC6302283 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Yeang Calvin C Hasanally Devin D Que Xuchu X Hung Ming-Yow MY Stamenkovic Aleksandra A Chan David D Chaudhary Rakesh R Margulets Victoria V Edel Andrea L AL Hoshijima Masahiko M Gu Yusu Y Bradford William W Dalton Nancy N Miu Phuong P Cheung David Yc DY Jassal Davinder S DS Pierce Grant N GN Peterson Kirk L KL Kirshenbaum Lorrie A LA Witztum Joseph L JL Tsimikas Sotirios S Ravandi Amir A
Cardiovascular research 20190101 1
<h4>Aims</h4>Myocardial ischaemia followed by reperfusion (IR) causes an oxidative burst resulting in cellular dysfunction. Little is known about the impact of oxidative stress on cardiomyocyte lipids and their role in cardiac cell death. Our goal was to identify oxidized phosphatidylcholine-containing phospholipids (OxPL) generated during IR, and to determine their impact on cell viability and myocardial infarct size.<h4>Methods and results</h4>OxPL were quantitated in isolated rat cardiomyocyt ...[more]