Ontology highlight
ABSTRACT:
SUBMITTER: Atakpa P
PROVIDER: S-EPMC6302550 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Atakpa Peace P Thillaiappan Nagendra Babu NB Mataragka Stefania S Prole David L DL Taylor Colin W CW
Cell reports 20181201 11
Inositol 1,4,5-trisphosphate (IP<sub>3</sub>) receptors (IP<sub>3</sub>Rs) allow extracellular stimuli to redistribute Ca<sup>2+</sup> from the ER to cytosol or other organelles. We show, using small interfering RNA (siRNA) and vacuolar H<sup>+</sup>-ATPase (V-ATPase) inhibitors, that lysosomes sequester Ca<sup>2+</sup> released by all IP<sub>3</sub>R subtypes, but not Ca<sup>2+</sup> entering cells through store-operated Ca<sup>2+</sup> entry (SOCE). A low-affinity Ca<sup>2+</sup> sensor target ...[more]