Ontology highlight
ABSTRACT:
SUBMITTER: Kwong JQ
PROVIDER: S-EPMC6302934 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Kwong Jennifer Q JQ Huo Jiuzhou J Bround Michael J MJ Boyer Justin G JG Schwanekamp Jennifer A JA Ghazal Nasab N Maxwell Joshua T JT Jang Young C YC Khuchua Zaza Z Shi Kevin K Bers Donald M DM Davis Jennifer J Molkentin Jeffery D JD
JCI insight 20181115 22
The mitochondrial Ca2+ uniporter (MCU) complex mediates acute mitochondrial Ca2+ influx. In skeletal muscle, MCU links Ca2+ signaling to energy production by directly enhancing the activity of key metabolic enzymes in the mitochondria. Here, we examined the role of MCU in skeletal muscle development and metabolic function by generating mouse models for the targeted deletion of Mcu in embryonic, postnatal, and adult skeletal muscle. Loss of Mcu did not affect muscle growth and maturation or other ...[more]