Ontology highlight
ABSTRACT:
SUBMITTER: Braud L
PROVIDER: S-EPMC6302946 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Braud Laura L Pini Maria M Muchova Lucie L Manin Sylvie S Kitagishi Hiroaki H Sawaki Daigo D Czibik Gabor G Ternacle Julien J Derumeaux Geneviève G Foresti Roberta R Motterlini Roberto R
JCI insight 20181115 22
Obesity is characterized by accumulation of adipose tissue and is one the most important risk factors in the development of insulin resistance. Carbon monoxide-releasing (CO-releasing) molecules (CO-RMs) have been reported to improve the metabolic profile of obese mice, but the underlying mechanism remains poorly defined. Here, we show that oral administration of CORM-401 to obese mice fed a high-fat diet (HFD) resulted in a significant reduction in body weight gain, accompanied by a marked impr ...[more]