Ontology highlight
ABSTRACT:
SUBMITTER: Averbukh I
PROVIDER: S-EPMC6303102 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Averbukh Inna I Lai Sen-Lin SL Doe Chris Q CQ Barkai Naama N
eLife 20181210
Biological timers synchronize patterning processes during embryonic development. In the <i>Drosophila</i> embryo, neural progenitors (neuroblasts; NBs) produce a sequence of unique neurons whose identities depend on the sequential expression of temporal transcription factors (TTFs). The stereotypy and precision of NB lineages indicate reproducible TTF timer progression. We combine theory and experiments to define the timer mechanism. The TTF timer is commonly described as a relay of activators, ...[more]