Ontology highlight
ABSTRACT:
SUBMITTER: Brockmann L
PROVIDER: S-EPMC6303294 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nature communications 20181221 1
IL-10 is a prototypical anti-inflammatory cytokine, which is fundamental to the maintenance of immune homeostasis, especially in the intestine. There is an assumption that cells producing IL-10 have an immunoregulatory function. However, here we report that IL-10-producing CD4<sup>+</sup> T cells are phenotypically and functionally heterogeneous. By combining single cell transcriptome and functional analyses, we identified a subpopulation of IL-10-producing Foxp3<sup>neg</sup> CD4<sup>+</sup> T ...[more]