Ontology highlight
ABSTRACT:
SUBMITTER: Gannon HS
PROVIDER: S-EPMC6303303 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nature communications 20181221 1
Systematic exploration of cancer cell vulnerabilities can inform the development of novel cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we identify adenosine deaminase acting on RNA (ADAR or ADAR1) as an essential gene for the survival of a subset of cancer cell lines. ADAR1-dependent cell lines display increased expression of interferon-stimulated genes. Activation of type I interferon signaling in the context of ADAR1 deficiency can induce cell lethalit ...[more]