Piconewton Mechanical Forces Promote Neurite Growth.
Ontology highlight
ABSTRACT:
SUBMITTER: Raffa V
PROVIDER: S-EPMC6303536 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Piconewton Mechanical Forces Promote Neurite Growth.
Raffa Vittoria V Falcone Francesca F De Vincentiis Sara S Falconieri Alessandro A Calatayud Maria P MP Goya Gerardo F GF Cuschieri Alfred A
Biophysical journal 20181016 10
Investigations over half a century have indicated that mechanical forces induce neurite growth, with neurites elongating at a rate of 0.1-0.3 μm h<sup>-1</sup> pN<sup>-1</sup> when mechanical force exceeds a threshold, with this being identified as 400-1000 pN for neurites of PC12 cells. In this article, we demonstrate that neurite elongation of PC12 cells proceeds at the same previously identified rate on application of mechanical tension of ∼1 pN, which is significantly lower than the force ge ...[more]
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