Ontology highlight
ABSTRACT:
SUBMITTER: Sohn M
PROVIDER: S-EPMC6305386 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Sohn Minji M Kim Myeong Gyu MG Han Nayoung N Kim In-Wha IW Gim Jungsoo J Min Sang-Il SI Song Eun Young EY Kim Yon Su YS Jung Hun Soon HS Shin Young Kee YK Ha Jongwon J Oh Jung Mi JM
Scientific reports 20181224 1
The purpose of this study was to identify genotypes associated with dose-adjusted tacrolimus trough concentrations (C<sub>0</sub>/D) in kidney transplant recipients using whole-exome sequencing (WES). This study included 147 patients administered tacrolimus, including seventy-five patients in the discovery set and seventy-two patients in the replication set. The patient genomes in the discovery set were sequenced using WES. Also, known tacrolimus pharmacokinetics-related intron variants were gen ...[more]