Blood Levels of Glutamate and Glutamine in Recent Onset and Chronic Schizophrenia.
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ABSTRACT:
SUBMITTER: Madeira C
PROVIDER: S-EPMC6305751 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Blood Levels of Glutamate and Glutamine in Recent Onset and Chronic Schizophrenia.
Madeira Caroline C Alheira Flavio V FV Calcia Marilia A MA Silva Thuany C S TCS Tannos Filippe M FM Vargas-Lopes Charles C Fisher Melissa M Goldenstein Nelson N Brasil Marco Antonio MA Vinogradov Sophia S Ferreira Sergio T ST Panizzutti Rogerio R
Frontiers in psychiatry 20181219
Converging evidence indicates that dysfunctions in glutamatergic neurotransmission and in the glutamate-glutamine cycle play a role in the pathophysiology of schizophrenia. Here, we investigated glutamate and glutamine levels in the blood of patients with recent onset schizophrenia or chronic schizophrenia compared to healthy controls. Compared with healthy controls, patients with recent onset schizophrenia showed increased glutamine/glutamate ratio, while patients with chronic schizophrenia sho ...[more]
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