Ontology highlight
ABSTRACT:
SUBMITTER: Buchwald ZS
PROVIDER: S-EPMC6306034 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Buchwald Zachary S ZS Wynne Jacob J Nasti Tahseen H TH Zhu Simeng S Mourad Waleed F WF Yan Weisi W Gupta Seema S Khleif Samir N SN Khan Mohammad K MK
Frontiers in oncology 20181213
The combination of radiation and immunotherapy is currently an exciting avenue of pre-clinical and clinical investigation. The synergy between these two treatment modalities has the potential to expand the role of radiation from a purely local therapy, to a role in advanced and metastatic disease. Tumor regression outside of the irradiated field, known as the abscopal effect, is a recognized phenomenon mediated by lymphocytes and enhanced by checkpoint blockade. In this review, we summarize the ...[more]