Dataset Information
Establishing Pediatric and Adult RBC Reference Intervals With NHANES Data Using Piecewise Regression.
Ontology highlight
ABSTRACT: Objectives
To develop age- and sex-specific RBC reference intervals using the National Health and Nutrition Examination Survey (NHANES) 1999 to 2012, a large nationally representative, population-based, cross-sectional database (n = 44,328).Methods
Comprehensive medical data were used to define a "healthy" population. Reference intervals for RBC count, hemoglobin, hematocrit, mean cell hemoglobin, mean cell hemoglobin concentration, mean cell volume, and red cell distribution width were computed using piecewise regression, an evidence-based statistical procedure that identifies breakpoints.Results
The derived reference intervals were sex specific, unlike many current standards, and more precise for individuals of different ages, especially for children, adolescents, and elderly individuals, as additional breakpoints were detected for these groups. Suggested reference values for hematocrit and hemoglobin of older adult males were substantially lower than current values.Conclusions
The reference intervals provided here, based on a large, nationally representative healthy population, contribute to the ongoing transition to precision medicine.
SUBMITTER: Fulgoni VL
PROVIDER: S-EPMC6306047 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Establishing Pediatric and Adult RBC Reference Intervals With NHANES Data Using Piecewise Regression.
American journal of clinical pathology 20190101 2
<h4>Objectives</h4>To develop age- and sex-specific RBC reference intervals using the National Health and Nutrition Examination Survey (NHANES) 1999 to 2012, a large nationally representative, population-based, cross-sectional database (n = 44,328).<h4>Methods</h4>Comprehensive medical data were used to define a "healthy" population. Reference intervals for RBC count, hemoglobin, hematocrit, mean cell hemoglobin, mean cell hemoglobin concentration, mean cell volume, and red cell distribution wid ...[more]