Dataset Information

Establishing Pediatric and Adult RBC Reference Intervals With NHANES Data Using Piecewise Regression.

ABSTRACT:

Objectives

To develop age- and sex-specific RBC reference intervals using the National Health and Nutrition Examination Survey (NHANES) 1999 to 2012, a large nationally representative, population-based, cross-sectional database (n = 44,328).

Methods

Comprehensive medical data were used to define a "healthy" population. Reference intervals for RBC count, hemoglobin, hematocrit, mean cell hemoglobin, mean cell hemoglobin concentration, mean cell volume, and red cell distribution width were computed using piecewise regression, an evidence-based statistical procedure that identifies breakpoints.

Results

The derived reference intervals were sex specific, unlike many current standards, and more precise for individuals of different ages, especially for children, adolescents, and elderly individuals, as additional breakpoints were detected for these groups. Suggested reference values for hematocrit and hemoglobin of older adult males were substantially lower than current values.

Conclusions

The reference intervals provided here, based on a large, nationally representative healthy population, contribute to the ongoing transition to precision medicine.

SUBMITTER: Fulgoni VL

PROVIDER: S-EPMC6306047 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Establishing Pediatric and Adult RBC Reference Intervals With NHANES Data Using Piecewise Regression.

Fulgoni Victor L VL Agarwal Sanjiv S Kellogg Mark D MD Lieberman Harris R HR

American journal of clinical pathology 20190101 2

<h4>Objectives</h4>To develop age- and sex-specific RBC reference intervals using the National Health and Nutrition Examination Survey (NHANES) 1999 to 2012, a large nationally representative, population-based, cross-sectional database (n = 44,328).<h4>Methods</h4>Comprehensive medical data were used to define a "healthy" population. Reference intervals for RBC count, hemoglobin, hematocrit, mean cell hemoglobin, mean cell hemoglobin concentration, mean cell volume, and red cell distribution wid ...[more]

PMID: 30285066

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Project description:BackgroundNuclear magnetic resonance (NMR) spectroscopy allows triglycerides to be subclassified into 14 different classes based on particle size and lipid content. We recently showed that these subfractions have differential associations with cardiovascular disease events. Here we report the distributions and define reference interval ranges for 14 triglyceride-containing lipoprotein subfraction metabolites.MethodsLipoprotein subfractions using the Nightingale NMR platform were measured in 9073 participants from four cohort studies contributing to the UCL-Edinburgh-Bristol consortium. The distribution of each metabolite was assessed, and reference interval ranges were calculated for a disease-free population, by sex and age group (<55, 55-65, >65 years), and in a subgroup population of participants with cardiovascular disease or type 2 diabetes. We also determined the distribution across body mass index and smoking status.ResultsThe largest reference interval range was observed in the medium very-low density lipoprotein subclass (2.5th 97.5th percentile; 0.08 to 0.68 mmol/L). The reference intervals were comparable among male and female participants, with the exception of triglyceride in high-density lipoprotein. Triglyceride subfraction concentrations in very-low density lipoprotein, intermediate-density lipoprotein, low-density lipoprotein and high-density lipoprotein subclasses increased with increasing age and increasing body mass index. Triglyceride subfraction concentrations were significantly higher in ever smokers compared to never smokers, among those with clinical chemistry measured total triglyceride greater than 1.7 mmol/L, and in those with cardiovascular disease, and type 2 diabetes as compared to disease-free subjects.ConclusionThis is the first study to establish reference interval ranges for 14 triglyceride-containing lipoprotein subfractions in samples from the general population measured using the nuclear magnetic resonance platform. The utility of nuclear magnetic resonance lipid measures may lead to greater insights for the role of triglyceride in cardiovascular disease, emphasizing the importance of appropriate reference interval ranges for future clinical decision making.

Dataset Information

Establishing Pediatric and Adult RBC Reference Intervals With NHANES Data Using Piecewise Regression.

Objectives

Methods

Results

Conclusions

Publications

Establishing Pediatric and Adult RBC Reference Intervals With NHANES Data Using Piecewise Regression.

Similar Datasets

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