Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults.
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ABSTRACT: Background
DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health.Methods
We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n?=?18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariable regression models were fitted to examine its association with exposure to prenatal and own adult smoking. DNA methylation levels were analysed in relation to body mass index (BMI), waist circumference (WC), fasting glucose (FG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), diastolic, and systolic blood pressure (BP).Findings
Lower DNA methylation at three out of eight GFI1-CpGs was associated with exposure to maternal prenatal smoking, whereas, all eight CpGs were associated with adult own smoking. Lower DNA methylation at cg14179389, the strongest maternal prenatal smoking locus, was associated with increased WC and BP when adjusted for sex, age, and adult smoking with Bonferroni-corrected P?-7?-8?InterpretationEpigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors. FUND: European Union's Horizon 2020 research and innovation programme under grant agreement no. 633595 DynaHEALTH.
SUBMITTER: Parmar P
PROVIDER: S-EPMC6306313 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults.
Parmar Priyanka P Lowry Estelle E Cugliari Giovanni G Suderman Matthew M Wilson Rory R Karhunen Ville V Andrew Toby T Wiklund Petri P Wielscher Matthias M Guarrera Simonetta S Teumer Alexander A Lehne Benjamin B Milani Lili L de Klein Niek N Mishra Pashupati P PP Melton Phillip E PE Mandaviya Pooja R PR Kasela Silva S Nano Jana J Zhang Weihua W Zhang Yan Y Uitterlinden Andre G AG Peters Annette A Schöttker Ben B Gieger Christian C Anderson Denise D Boomsma Dorret I DI Grabe Hans J HJ Panico Salvatore S Veldink Jan H JH van Meurs Joyce B J JBJ van den Berg Leonard L Beilin Lawrence J LJ Franke Lude L Loh Marie M van Greevenbroek Marleen M J MMJ Nauck Matthias M Kähönen Mika M Hurme Mikko A MA Raitakari Olli T OT Franco Oscar H OH Slagboom P Eline PE van der Harst Pim P Kunze Sonja S Felix Stephan B SB Zhang Tao T Chen Wei W Mori Trevor A TA Bonnefond Amelie A Heijmans Bastiaan T BT Muka Taulant T Kooner Jaspal S JS Fischer Krista K Waldenberger Melanie M Froguel Philippe P Huang Rae-Chi RC Lehtimäki Terho T Rathmann Wolfgang W Relton Caroline L CL Matullo Giuseppe G Brenner Hermann H Verweij Niek N Li Shengxu S Chambers John C JC Järvelin Marjo-Riitta MR Sebert Sylvain S
EBioMedicine 20181113
<h4>Background</h4>DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health.<h4>Methods</h4>We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Eu ...[more]
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