Ontology highlight
ABSTRACT:
SUBMITTER: Zang J
PROVIDER: S-EPMC6306944 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Zang Jingjing J Neuhauss Stephan C F SCF
Frontiers in molecular neuroscience 20181220
Recoverin (Rcv) is a low molecular-weight, neuronal calcium sensor (NCS) primarily located in photoreceptor outer segments of the vertebrate retina. Calcium ions (Ca<sup>2+</sup>)-bound Rcv has been proposed to inhibit G-protein-coupled receptor kinase (GRKs) in darkness. During the light response, the Ca<sup>2+</sup>-free Rcv releases GRK, which in turn phosphorylates visual pigment, ultimately leading to the cessation of the visual transduction cascade. Technological advances over the last dec ...[more]