Dataset Information

Statin treatment, oxidative stress and inflammation in a Danish population.

ABSTRACT:

Background

While statins may have anti-inflammatory effects, anti-oxidative effects are controversial. We investigated if statin treatment is associated with differences in oxidatively generated nucleotide damage and chronic inflammation, and the relationship between nucleotide damage and chronic inflammation.

Methods

We included 19,795 participants from the Danish General Suburban Population Study. In 3420 participants, we measured urinary 8-oxodG and 8-oxoGuo by liquid chromatography-tandem mass spectrometry as markers of oxidatively generated damage to DNA and RNA, respectively. We used a composite score for chronic inflammation (INFLA score) of hsCRP, WBC, platelet count, and neutrophil granulocyte to lymphocyte ratio. Associations were assessed using multivariate linear regression models.

Results

Compared with non-users, statin users had 4.3-6.0% lower 8-oxodG in three separate models (p??60?y, statin users had 11.4% lower 8-oxodG (95%CI: 6.7-15.9%, p_interaction<0.001) and 3.9% lower 8-oxoGuo (95%CI: 0.1-7.5%, p_interaction =?0.002), compared with non-users. Compared with non-users, statin users had 11.1% (95%CI: 5.4-16.5%, p_interaction<0.001) lower 8-oxodG in participants treated for hypertension, and 18.6% (95%CI: 6.8-28.9%, p_interaction<0.001) lower 8-oxodG in participants with decreased renal function. Compared with non-users, statin users had significantly lower INFLA score (p?ConclusionsOxidatively generated DNA damage and inflammatory burden are lower in statin users compared with non-users. Together, anti-oxidative and anti-inflammatory effects may contribute to the beneficial effects of statins.

SUBMITTER: Sorensen AL

PROVIDER: S-EPMC6307042 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Publications

Statin treatment, oxidative stress and inflammation in a Danish population.

Sørensen Anders L AL Hasselbalch Hans C HC Nielsen Claus H CH Poulsen Henrik E HE Ellervik Christina C

Redox biology 20181221

<h4>Background</h4>While statins may have anti-inflammatory effects, anti-oxidative effects are controversial. We investigated if statin treatment is associated with differences in oxidatively generated nucleotide damage and chronic inflammation, and the relationship between nucleotide damage and chronic inflammation.<h4>Methods</h4>We included 19,795 participants from the Danish General Suburban Population Study. In 3420 participants, we measured urinary 8-oxodG and 8-oxoGuo by liquid chromatog ...[more]

PMID: 30594900

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Dataset Information

Statin treatment, oxidative stress and inflammation in a Danish population.

Background

Methods

Results

Publications

Statin treatment, oxidative stress and inflammation in a Danish population.

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