Ontology highlight
ABSTRACT:
SUBMITTER: Nurtop E
PROVIDER: S-EPMC6307276 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nurtop Elif E Villarroel Paola Mariela Saba PMS Pastorino Boris B Ninove Laetitia L Drexler Jan Felix JF Roca Yelin Y Gake Bouba B Dubot-Peres Audrey A Grard Gilda G Peyrefitte Christophe C Priet Stéphane S de Lamballerie Xavier X Gallian Pierre P
Virology journal 20181227 1
Here we propose a strategy allowing implementing efficient and practicable large-scale seroepidemiological studies for Zika Virus (ZIKV). It combines screening by a commercial NS1 protein-based Zika IgG ELISA, and confirmation by a cytopathic effect-based virus neutralization test (CPE-based VNT). In post-epidemic samples from Martinique Island blood donors (a population with a dengue seroprevalence above 90%), this strategy allowed reaching specificity and sensitivity values over 98%. The CPE-b ...[more]