Ontology highlight
ABSTRACT:
SUBMITTER: Li Yim AYF
PROVIDER: S-EPMC6307755 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Li Yim Andrew Y F AYF de Bruyn Jessica R JR Duijvis Nicolette W NW Sharp Catriona C Ferrero Enrico E de Jonge Wouter J WJ Wildenberg Manon E ME Mannens Marcel M A M MMAM Buskens Christianne J CJ D'Haens Geert R GR Henneman Peter P Te Velde Anje A AA
PloS one 20181227 12
<h4>Background</h4>The chronic remitting and relapsing intestinal inflammation characteristic of Crohn's disease frequently leads to fibrosis and subsequent stenosis of the inflamed region. Approximately a third of all Crohn's disease patients require resection at some stage in their disease course. As the pathogenesis of Crohn's disease associated fibrosis is largely unknown, a strong necessity exists to better understand the pathophysiology thereof.<h4>Methods</h4>In this study, we investigate ...[more]