Ontology highlight
ABSTRACT:
SUBMITTER: Pickering RJ
PROVIDER: S-EPMC6307942 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Pickering Raelene J RJ Tikellis Christos C Rosado Carlos J CJ Tsorotes Despina D Dimitropoulos Alexandra A Smith Monique M Huet Olivier O Seeber Ruth M RM Abhayawardana Rekhati R Johnstone Elizabeth Km EK Golledge Jonathan J Wang Yutang Y Jandeleit-Dahm Karin A KA Cooper Mark E ME Pfleger Kevin Dg KD Thomas Merlin C MC
The Journal of clinical investigation 20181210 1
Activation of the type 1 angiotensin II receptor (AT1) triggers proinflammatory signaling through pathways independent of classical Gq signaling that regulate vascular homeostasis. Here, we report that the AT1 receptor preformed a heteromeric complex with the receptor for advanced glycation endproducts (RAGE). Activation of the AT1 receptor by angiotensin II (Ang II) triggered transactivation of the cytosolic tail of RAGE and NF-κB-driven proinflammatory gene expression independently of the libe ...[more]