High-affinity T cell receptors for adoptive cell transfer.
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ABSTRACT:
SUBMITTER: Isser A
PROVIDER: S-EPMC6307956 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
High-affinity T cell receptors for adoptive cell transfer.
Isser Ariel A Schneck Jonathan P JP
The Journal of clinical investigation 20181210 1
Adoptive cell transfer (ACT) of engineered T cell receptors (TCRs) for cancer immunotherapy has evolved from simple gene transfer of isolated TCRs to various affinity enhancement techniques that overcome limitations imposed by central and peripheral tolerance on TCR affinity. In the current issue of the JCI, Poncette et al. used mice with human TCRαβ and HLA gene loci to discover CD4+ TCRs of optimal affinity for cancer testis antigen (CTA) NY-ESO-1. They combined this TCR with a previously disc ...[more]
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