Dataset Information

Supervised versus autonomous exercise training in breast cancer patients: A multicenter randomized clinical trial.

ABSTRACT: BACKGROUND:There is a well-known correlation between obesity, sedentary lifestyle, and breast cancer incidence and outcome. The Arbeitsgemeinschaft Medikamentöse Tumortherapie (AGMT) exercise study was a multicenter, randomized clinical trial and assessed the feasibility and efficacy of physical training in 50 breast cancer patients undergoing aromatase inhibitor treatment. METHODS:Postmenopausal, estrogen receptor-positive breast cancer patients under aromatase inhibitor treatment were randomized 1:1 to counseling and unsupervised training for 48 weeks (unsupervised arm) or counseling and a sequential training (supervised arm) with a supervised phase (24 weeks) followed by unsupervised physical training (further 24 weeks). Primary endpoint was the individual maximum power output on a cycle ergometer after 24 weeks of exercise. A key secondary endpoint was the feasibility of achieving 12 METh/week (metabolic equivalent of task hours per week). RESULTS:Twenty-three patients (92%) in the unsupervised arm and 19 patients (76%) in the supervised arm with early-stage breast cancer completed the study. After 24 weeks, the supervised arm achieved a significantly higher maximum output in watt (mean 132 ± standard deviation [SD] 34; 95% confidence interval [CI] 117-147) compared to baseline (107 ± 25; 95%CI 97-117; P = 0.012) with a numerically higher output than the unsupervised arm (week 24 115 ± 25; 95%CI 105-125; P = 0.059). Significantly higher METh/week was reported in the supervised arm compared to the unsupervised arm during the whole study period (week 1-24 unsupervised: 18.3 (7.6-58.3); supervised: 28.5 (6.7-40.1); P = 0.043; week 25-48; P = 0.041)). CONCLUSION:This trial indicates that patients in an exercise program achieve higher fitness levels during supervised than unsupervised training.

SUBMITTER: Westphal T

PROVIDER: S-EPMC6308077 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Supervised versus autonomous exercise training in breast cancer patients: A multicenter randomized clinical trial.

Westphal Theresa T Rinnerthaler Gabriel G Gampenrieder Simon Peter SP Niebauer Josef J Thaler Josef J Pfob Michael M Fuchs David D Riedmann Marina M Mayr Barbara B Reich Bernhard B Melchardt Thomas T Mlineritsch Brigitte B Pleyer Lisa L Greil Richard R

Cancer medicine 20181110 12

<h4>Background</h4>There is a well-known correlation between obesity, sedentary lifestyle, and breast cancer incidence and outcome. The Arbeitsgemeinschaft Medikamentöse Tumortherapie (AGMT) exercise study was a multicenter, randomized clinical trial and assessed the feasibility and efficacy of physical training in 50 breast cancer patients undergoing aromatase inhibitor treatment.<h4>Methods</h4>Postmenopausal, estrogen receptor-positive breast cancer patients under aromatase inhibitor treatmen ...[more]

PMID: 30415507

Similar Datasets

Project description:BackgroundAmong the most effective therapeutic interventions in non-specific chronic low back pain, clinical practice guidelines highlight exercise therapy and patient education. However, the variability in the type of exercise and its dosage means that there is no clear evidence regarding the most optimal form of therapeutic exercise.AimThe main objective of this study was to ascertain the effects produced by two different exercise interventions (supervised exercise therapy and laser-guided exercise therapy) and pain neuroscience education on postural control measured by the displacement center of pressure (CoP) and energy spectral density (ESD) in subjects with non-specific chronic low back pain.DesignThis is a single-blinded randomized clinical comparative controlled trial.SettingThe study was carried out in different private physiotherapy care centers.PopulationWe enrolled 60 subjects with non-specific chronic low back pain of at least 3-month duration, aged 18-45 years.MethodsBoth groups performed a total of 16 therapeutic exercise sessions and 8 pain neuroscience education sessions, with the laser-guided exercise therapy group performing laser-guided exercises. The main outcome measures evaluated were ESD and displacement of CoP measured at 3 different times (baseline, post-treatment, and 3 month follow-up).ResultsThe most important differences for ESD and displacement of CoP variables were obtained for eyes open, unstable surface anteroposterior axis (F(2,92)=7.36, P=0.001, d=0.71) and eyes closed, stable surface mediolateral axis (F(2,92)=3.24, P<0.001, d=0.76). Further, time × group interactions showed significant statistical differences in both cases as well as significant differences between baseline and 3 month's follow-up.ConclusionsBoth exercise modalities (supervised exercise therapy and laser-guided exercise therapy) showed changes in variables related to postural control (displacement of CoP and ESD). However, the laser-guided exercise therapy program showed greater improvements in ESD.Clinical rehabilitation impactAnalysis of a new approach for the quantification of data obtained from postural control assessment relying on widely used devices (accelerometers and pressure platforms).

Project description:BACKGROUND:Visceral adipose tissue (VAT) is a strong risk factor for cardiovascular disease and increases with age. While supervised exercise (SE) may be an effective approach, web-based exercise (WE) have other advantages such as being more readily accessible. Therefore, we evaluated the effects of WE on VAT, body composition and cardiometabolic risk markers in centrally obese older adults and compared the effects of WE to SE. We also explored the feasibility of WE. METHODS:In a randomized controlled trial conducted in Umeå, Sweden during January 2018 - November 2018, N?=?77, 70-year-old men and women with central obesity (>?1?kg VAT for women, >?2?kg for men) were randomized to an intervention group (n?=?38) and a wait-list control group (n?=?39). The intervention group received 10?weeks of SE while the wait-list control group lived as usual. Following a 10-week wash-out-period, the wait-list control group received 10?weeks of WE. The primary outcome was changes in VAT. Secondary outcomes included changes in fat mass (FM), lean body mass (LBM), blood lipids, fasting blood glucose. Additionally, we explored the feasibility of WE defined as adherence and participant experiences. RESULTS:WE had no significant effect on VAT (P?=?0.5), although it decreased FM by 450?g (95% confidence interval [CI], 37 to 836, P?<?0.05). The adherence to WE was 85% and 87-97% of the participants rated aspects of the WE intervention >?4 on a scale of 1-5. Comparing SE to WE, there was no significant difference in decrease of VAT (Cohen's ? effect size [ES], 0.5, 95% CI, -?24 to 223, P?=?0.11), although SE decreased FM by 619?g (ES, 0.5, 95% CI, 22 to 1215, P?<?0.05) compared to WE. CONCLUSIONS:Ten weeks of vigorous WE is insufficient to decrease VAT in centrally obese older adults, but sufficient to decrease FM while preserving LBM. The high adherence and positive experiences of the WE intervention implies that it could serve as an alternative exercise strategy for older adults with central obesity, with increased availability for a larger population. TRIAL REGISTRATION:ClinicalTrials.gov (NCT03450655), retrospectively registered February 28, 2018.

Project description:BackgroundPhysical activity (PA) during pregnancy is an effective and safe way to improve maternal health in uncomplicated pregnancies. However, compliance with PA recommendations remains low among pregnant women.ObjectiveThe purpose of this study was to evaluate the effects of offering structured supervised exercise training (EXE) or motivational counseling on PA (MOT) during pregnancy on moderate-to-vigorous intensity physical activity (MVPA) level. Additionally, complementary measures of PA using the Pregnancy Physical Activity Questionnaire (PPAQ) and gold standard doubly labeled water (DLW) technique were investigated. The hypotheses were that both EXE and MOT would increase MVPA in pregnancy compared with standard care (CON) and that EXE would be more effective than MOT. In addition, the association between MVPA and the number of sessions attended was explored.MethodsA randomized controlled trial included 220 healthy, inactive pregnant women with a median gestational age of 12.9 (IQR 9.4-13.9) weeks. A total of 219 women were randomized to CON (45/219), EXE (87/219), or MOT (87/219). The primary outcome was MVPA (minutes per week) from randomization to the 29th gestational week obtained by a wrist-worn commercial activity tracker (Vivosport, Garmin International). PA was measured by the activity tracker throughout pregnancy, PPAQ, and DLW. The primary outcome analysis was performed as an analysis of covariance model adjusting for baseline PA.ResultsThe average MVPA (minutes per week) from randomization to the 29th gestational week was 33 (95% CI 18 to 47) in CON, 50 (95% CI 39 to 60) in EXE, and 40 (95% CI 30 to 51) in MOT. When adjusted for baseline MVPA, participants in EXE performed 20 (95% CI 4 to 36) minutes per week more MVPA than participants in CON (P=.02). MOT was not more effective than CON; EXE and MOT also did not differ. MVPA was positively associated with the number of exercise sessions attended in EXE from randomization to delivery (P=.04). Attendance was higher for online (due to COVID-19 restrictions) compared with physical exercise training (P=.03). Adverse events and serious adverse events did not differ between groups.ConclusionsOffering EXE was more effective than CON to increase MVPA among pregnant women, whereas offering MOT was not. MVPA in the intervention groups did not reach the recommended level in pregnancy. Changing the intervention to online due to COVID-19 restrictions did not affect MVPA level but increased exercise participation.Trial registrationClinicalTrials.gov NCT03679130; https://clinicaltrials.gov/ct2/show/NCT03679130.International registered report identifier (irrid)RR2-10.1136/bmjopen-2020-043671.

Dataset Information

Supervised versus autonomous exercise training in breast cancer patients: A multicenter randomized clinical trial.

Publications

Supervised versus autonomous exercise training in breast cancer patients: A multicenter randomized clinical trial.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets