The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial.

ABSTRACT: BACKGROUND:Postprandial non-esterified fatty acid (NEFA) and triglyceride (TG) responses are increased in subjects with type 2 diabetes mellitus (T2DM) and may impair insulin action and increase risk of cardiovascular disease and death. Dietary carbohydrate reduction has been suggested as non-pharmacological therapy for T2DM, but the acute effects on NEFA and TG during subsequent meals remain to be investigated. METHODS:Postprandial NEFA and TG responses were assessed in subjects with T2DM by comparing a carbohydrate-reduced high-protein (CRHP) diet with a conventional diabetes (CD) diet in an open-label, randomized, cross-over study. Each diet was consumed on two consecutive days, separated by a wash-out period. The iso-caloric CRHP/CD diets contained 31/54 E% from carbohydrate, 29/16 E% energy from protein and 40/30 E% from fat, respectively. Sixteen subjects with well-controlled T2DM (median HbA1c 47?mmol/mol, (37-67?mmol/mol) and BMI 30?±?4.4?kg/m2) participated in the study. NEFA and TG were evaluated following breakfast and lunch. RESULTS:NEFA net area under curve (AUC) was increased by 97?±?38??mol/Lx270 min (p?=?0.024) after breakfast but reduced by 141?±?33??mol/Lx180 min (p?

SUBMITTER: Samkani A 

PROVIDER: S-EPMC6309080 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature