Ontology highlight
ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC6309271 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Zhang Weiqi W Tung Ching-Hsuan CH
Chemistry (Weinheim an der Bergstrasse, Germany) 20180116 9
Breaking the lysosome helps its sequestered payloads access their molecular targets in cells and thus enhances the intracellular drug delivery. Current strategies for lysosomal escape involve direct physical interactions with the lipid membrane. These interactions pose a systemic toxicity and uncontrolled membrane rupture risk. Here, we report a light-detonated lysosome disruption using a hyaluronan (HA) nanogel packed with toludine blue (TB). The HA/TB nanogel is concentrated within the lysosom ...[more]