Vitamin D supplementation attenuates asthma development following traffic-related particulate matter exposure.

ABSTRACT:

Background

Recent literature suggests that children who are vitamin D deficient are uniquely susceptible to the effects of traffic-related air pollution (TRAP) exposure. This is highly significant because large segments of the population reside in zones of high TRAP exposure.

Objective

We sought to determine whether vitamin D supplementation mitigates the effect of TRAP exposure on asthma development, asthma exacerbation, and/or airway inflammation and to determine the timing of vitamin D supplementation that confers maximal health benefit.

Methods

Using established mouse models of asthma, we examined the effect of prenatal and postnatal vitamin D supplementation on asthma development, as well as the utility of vitamin D as a treatment for established asthma in the co

SUBMITTER: Bolcas PE 

PROVIDER: S-EPMC6309534 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature