Dataset Information

Vitamin D supplementation attenuates asthma development following traffic-related particulate matter exposure.

ABSTRACT:

Background

Recent literature suggests that children who are vitamin D deficient are uniquely susceptible to the effects of traffic-related air pollution (TRAP) exposure. This is highly significant because large segments of the population reside in zones of high TRAP exposure.

Objective

We sought to determine whether vitamin D supplementation mitigates the effect of TRAP exposure on asthma development, asthma exacerbation, and/or airway inflammation and to determine the timing of vitamin D supplementation that confers maximal health benefit.

Methods

Using established mouse models of asthma, we examined the effect of prenatal and postnatal vitamin D supplementation on asthma development, as well as the utility of vitamin D as a treatment for established asthma in the context of diesel exhaust particle (DEP) exposure.

Results

DEP and allergen coexposure resulted in increased airway hyperresponsiveness (AHR) and accumulation of pathogenic T_H2/T_H17 cells in the lungs of vitamin D-deficient mice compared with control mice. Prenatal and postnatal vitamin D supplementation significantly attenuated the development of AHR and decreased pulmonary accumulation of T_H2/T_H17 cells after coexposure to TRAP and allergen but not to allergen alone. Restoration of normal vitamin D status had no effect on AHR once asthma was already established.

Conclusions

Our data establish that vitamin D confers protection against asthma development specifically in the context of TRAP exposure. Although vitamin D replacement did not reverse established asthma, restoration of normal vitamin D status in early life significantly attenuated the development of AHR in the setting of DEP-exacerbated allergic asthma and reduced numbers of lung T_H2/T_H17 cells, which portend the development of severe asthma.

SUBMITTER: Bolcas PE

PROVIDER: S-EPMC6309534 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Vitamin D supplementation attenuates asthma development following traffic-related particulate matter exposure.

Bolcas Paige E PE Brandt Eric B EB Zhang Zhonghua Z Biagini Myers Jocelyn M JM Ruff Brandy P BP Khurana Hershey Gurjit K GK

The Journal of allergy and clinical immunology 20180621 1

<h4>Background</h4>Recent literature suggests that children who are vitamin D deficient are uniquely susceptible to the effects of traffic-related air pollution (TRAP) exposure. This is highly significant because large segments of the population reside in zones of high TRAP exposure.<h4>Objective</h4>We sought to determine whether vitamin D supplementation mitigates the effect of TRAP exposure on asthma development, asthma exacerbation, and/or airway inflammation and to determine the timing of v ...[more]

PMID: 29936100

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Dataset Information

Vitamin D supplementation attenuates asthma development following traffic-related particulate matter exposure.

Background

Objective

Methods

Results

Conclusions

Publications

Vitamin D supplementation attenuates asthma development following traffic-related particulate matter exposure.

Similar Datasets

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