Ontology highlight
ABSTRACT:
SUBMITTER: Sahoo A
PROVIDER: S-EPMC6309654 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Sahoo Anupama A Sahoo Sanjaya K SK Joshi Piyush P Lee Bongyong B Perera Ranjan J RJ
The Journal of investigative dermatology 20180801 1
The clinical management of malignant melanoma remains a challenge because these tumors are intrinsically aggressive and prone to therapeutic resistance. MicroRNA (miR)-211 is an emerging melanoma oncogene. Melanoma metabolism adapts to promote survival, including in response to BRAF<sup>V600E</sup> inhibition, but how miR-211 participates in this process is unknown. Here, we generated miR-211 loss-of-function cell lines using CRISPR/Cas9 technology and show that miR-211 loss slowed growth and in ...[more]