Ontology highlight
ABSTRACT:
SUBMITTER: Corona A
PROVIDER: S-EPMC6309732 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Corona Angela A Desantis Jenny J Massari Serena S Distinto Simona S Masaoka Takashi T Sabatini Stefano S Esposito Francesca F Manfroni Giuseppe G Maccioni Elias E Cecchetti Violetta V Pannecouque Christophe C Le Grice Stuart F J SF Tramontano Enzo E Tabarrini Oriana O
ChemMedChem 20160316 16
Despite the significant progress achieved with combination antiretroviral therapy in the fight against human immunodeficiency virus (HIV) infection, the difficulty to eradicate the virus together with the rapid emergence of multidrug-resistant strains clearly underline a pressing need for innovative agents, possibly endowed with novel mechanisms of action. In this context, owing to its essential role in HIV genome replication, the reverse transcriptase associated ribonuclease H (RNase H) has pro ...[more]