Ontology highlight
ABSTRACT:
SUBMITTER: Peebles RS
PROVIDER: S-EPMC6309751 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Pharmacology & therapeutics 20180803
Prostaglandins are synthesized through the metabolism of arachidonic acid via the cyclooxygenase pathway. There are five primary prostaglandins, PGD<sub>2</sub>, PGE<sub>2</sub>, PGF<sub>2</sub>, PGI<sub>2</sub>, and thromboxane B<sub>2</sub>, that all signal through distinct seven transmembrane, G-protein coupled receptors. The receptors through which the prostaglandins signal determines their immunologic or physiologic effects. For instance, the same prostaglandin may have opposing properties, ...[more]