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Investigating a novel fMRI cannabis cue reactivity task in youth.

ABSTRACT: OBJECTIVE:Adult and adolescent studies suggest increased motivational responses to cannabis cues among regular cannabis users. However, functional magnetic resonance imaging (fMRI) studies have not explored neural activation in response to visual cannabis cues among adolescents in the United States. Gaining a better understanding of the neural circuits related to cue-elicited craving during adolescence may shed light on the neural basis for the development of problematic cannabis use that could ultimately be targeted for interventions. METHODS:41 non-treatment-seeking youth (ages 17-21; mean age?=?18.83; 46.3% female) who reported regular cannabis use underwent fMRI scanning involving a visual cannabis cue task and completed self-report and biological measures. Whole-brain activation was examined for cannabis cues compared to non-cannabis cues, and for active versus passive cannabis cues. Associations between self-reported substance use and task activation were examined. RESULTS:Cannabis images were identifiable to adolescents and were rated as more rewarding than matched non-cannabis images (p??0.05). No differences were observed for the active versus passive cue contrast. CONCLUSIONS:Cannabis-using youth show more activation to cannabis cues than non-cannabis cues in brain regions underlying incentive salience, reward, and visual attention. This task could be useful for future studies examining neural underpinnings of reward processes in adolescent cannabis users.

SUBMITTER: Karoly HC

PROVIDER: S-EPMC6309857 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Investigating a novel fMRI cannabis cue reactivity task in youth.

Karoly Hollis C HC Schacht Joseph P JP Meredith Lindsay R LR Jacobus Joanna J Tapert Susan F SF Gray Kevin M KM Squeglia Lindsay M LM

Addictive behaviors 20180911

<h4>Objective</h4>Adult and adolescent studies suggest increased motivational responses to cannabis cues among regular cannabis users. However, functional magnetic resonance imaging (fMRI) studies have not explored neural activation in response to visual cannabis cues among adolescents in the United States. Gaining a better understanding of the neural circuits related to cue-elicited craving during adolescence may shed light on the neural basis for the development of problematic cannabis use tha ...[more]

PMID: 30243035

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Investigating a novel fMRI cannabis cue reactivity task in youth.

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Investigating a novel fMRI cannabis cue reactivity task in youth.

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